Loss of functional System x-c uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-Ko mice

Mutations in Kv1.1 (Kcna1) voltage-gated potassium channels in humans and mice generate network hyperexcitability, enhancing aberrant postnatal neurogenesis in the dentate subgranular zone, resulting in epilepsy and hippocampal hypertrophy. While Kcna1 loss stimulates proliferation of progenitor cel...

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Detalles Bibliográficos
Autores principales: Aloi, Macarena S., Thompson, Samantha J., Quartapella, Nicholas, Noebels, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753929/
https://www.ncbi.nlm.nih.gov/pubmed/36417872
http://dx.doi.org/10.1016/j.celrep.2022.111696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753929/
https://www.ncbi.nlm.nih.gov/pubmed/36417872
http://dx.doi.org/10.1016/j.celrep.2022.111696

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