Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolimus, and ridaforolimus) are FDA approved as mTOR in...

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Detalles Bibliográficos
Autores principales: Shi, Guoli, Chiramel, Abhilash I., Li, Tiansheng, Lai, Kin Kui, Kenney, Adam D., Zani, Ashley, Eddy, Adrian C., Majdoul, Saliha, Zhang, Lizhi, Dempsey, Tirhas, Beare, Paul A., Kar, Swagata, Yewdell, Jonathan W., Best, Sonja M., Yount, Jacob S., Compton, Alex A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753997/
https://www.ncbi.nlm.nih.gov/pubmed/36264642
http://dx.doi.org/10.1172/JCI160766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753997/
https://www.ncbi.nlm.nih.gov/pubmed/36264642
http://dx.doi.org/10.1172/JCI160766

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