SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

The Hippo pathway nuclear effector Yes-associated protein (YAP) potentiates the progression of polycystic kidney disease (PKD) arising from ciliopathies. The mechanisms underlying the increase in YAP expression and transcriptional activity in PKD remain obscure. We observed that in kidneys from mice...

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Detalles Bibliográficos
Autores principales: Panda, Dibyendu K., Bai, Xiuying, Zhang, Yan, Stylianesis, Nicholas A., Koromilas, Antonis E., Lipman, Mark L., Karaplis, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754004/
https://www.ncbi.nlm.nih.gov/pubmed/36326820
http://dx.doi.org/10.1172/JCI153943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754004/
https://www.ncbi.nlm.nih.gov/pubmed/36326820
http://dx.doi.org/10.1172/JCI153943

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