Cargando…

SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

The Hippo pathway nuclear effector Yes-associated protein (YAP) potentiates the progression of polycystic kidney disease (PKD) arising from ciliopathies. The mechanisms underlying the increase in YAP expression and transcriptional activity in PKD remain obscure. We observed that in kidneys from mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Panda, Dibyendu K., Bai, Xiuying, Zhang, Yan, Stylianesis, Nicholas A., Koromilas, Antonis E., Lipman, Mark L., Karaplis, Andrew C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754004/ https://www.ncbi.nlm.nih.gov/pubmed/36326820 http://dx.doi.org/10.1172/JCI153943

Ejemplares similares

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase
por: Yoneyama, Yosuke, et al.
Publicado: (2018)

The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)
por: Roberts, Jamie Z., et al.
Publicado: (2020)

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases
por: Zhou, Weihua, et al.
Publicado: (2013)

The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores
por: Willhoft, Oliver, et al.
Publicado: (2017)

PI3K regulation of the SKP-2/p27 axis through mTORC2
por: Shanmugasundaram, Karthigayan, et al.
Publicado: (2012)

Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer
por: Geng, Qirong, et al.
Publicado: (2017)

DCUN1D3 activates SCF(SKP2) ubiquitin E3 ligase activity and cell cycle progression under UV damage
por: Zhang, Shuai, et al.
Publicado: (2016)

The role of SCF ubiquitin-ligase complex at the beginning of life
por: Xie, Jiayan, et al.
Publicado: (2019)

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
por: Baek, Kheewoong, et al.
Publicado: (2023)

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
por: Baek, Kheewoong, et al.
Publicado: (2023)

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development
por: Liu, Pin, et al.
Publicado: (2017)

Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase
por: Wang, Qian, et al.
Publicado: (2013)

Oxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in development of the social amoeba Dictyostelium
por: Boland, Andrew W., et al.
Publicado: (2022)

Regulation of SCF(TIR1/AFBs) E3 ligase assembly by S-nitrosylation of Arabidopsis SKP1-like1 impacts on auxin signaling
por: Iglesias, María José, et al.
Publicado: (2018)

Hijacking of the Host SCF Ubiquitin Ligase Machinery by Plant Pathogens
por: Magori, Shimpei, et al.
Publicado: (2011)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

SCF(Fbxl3) Ubiquitin Ligase Targets Cryptochromes at Their Cofactor Pocket
por: Xing, Weiman, et al.
Publicado: (2013)

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL
por: Rodriguez, Sonia, et al.
Publicado: (2019)

Phytochemical library screening reveals betulinic acid as a novel Skp2‐SCF E3 ligase inhibitor in non–small cell lung cancer
por: He, Dan‐Hua, et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Translational regulation of the expression of the ubiquitin E3 ligase Nedd4–1 by mTORC1-dependent signaling
por: Hsia, Hung-En, et al.
Publicado: (2015)

SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity
por: Yao, Fan, et al.
Publicado: (2018)

SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity
por: Yao, Fan, et al.
Publicado: (2018)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers
por: BOCHIS, OVIDIU VASILE, et al.
Publicado: (2015)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
por: Hoxhaj, Gerta, et al.
Publicado: (2016)

The ubiquitin ligase Nedd4-2 mediates the regulation of PepT2 by mTORC1 in bovine mammary epithelial cells
por: Wang, Caihong, et al.
Publicado: (2022)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics
por: Holmes, Brent, et al.
Publicado: (2021)

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes
por: Cardozo, Timothy, et al.
Publicado: (2007)

The SCF(FBW7) ubiquitin ligase complex as a tumor suppressor in T cell leukemia
por: Thompson, Benjamin J., et al.
Publicado: (2007)

Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor
por: Aghajanyy, Mariam, et al.
Publicado: (2010)

SCF(Cdc4) ubiquitin ligase regulates synaptonemal complex formation during meiosis
por: Zhu, Zhihui, et al.
Publicado: (2020)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_udifrl5emocv5bmcf4e0dqluqg