NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells

Acute myeloid leukemia (AML) stem cells are required for the initiation and maintenance of the disease. Activation of the Wnt/β-catenin pathway is required for the survival and development of AML leukaemia stem cells (LSCs) and therefore, targeting β-catenin is a potential therapeutic strategy. NUC-...

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Detalles Bibliográficos
Autores principales: Shahid, Akbar Muhammed, Um, In Hwa, Elshani, Mustafa, Zhang, Ying, Harrison, David James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754587/
https://www.ncbi.nlm.nih.gov/pubmed/36520954
http://dx.doi.org/10.1371/journal.pone.0278209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754587/
https://www.ncbi.nlm.nih.gov/pubmed/36520954
http://dx.doi.org/10.1371/journal.pone.0278209

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