Z-REX uncovers a bifurcation in function of Keap1 paralogs

Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-à-vis off-target, modifications. By combining bolus dosing, knockdown, and Z-REX—a tool investigating on-target/on-pathway electrophile signaling, we document that electrophile...

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Detalles Bibliográficos
Autores principales: Van Hall-Beauvais, Alexandra, Poganik, Jesse R, Huang, Kuan-Ting, Parvez, Saba, Zhao, Yi, Lin, Hong-Yu, Liu, Xuyu, Long, Marcus John Curtis, Aye, Yimon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754640/
https://www.ncbi.nlm.nih.gov/pubmed/36300632
http://dx.doi.org/10.7554/eLife.83373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754640/
https://www.ncbi.nlm.nih.gov/pubmed/36300632
http://dx.doi.org/10.7554/eLife.83373

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