Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier

Maintenance of epithelial barrier function requires dynamic repair and remodeling of tight junctions. In this issue, Higashi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202204079) demonstrate that the proteolytic cleavage of EpCAM by membrane-anchored serine proteinases releases Claudin-...

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Detalles Bibliográficos
Autores principales: Varadarajan, Saranyaraajan, Raya-Sandino, Arturo, Nusrat, Asma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754701/
https://www.ncbi.nlm.nih.gov/pubmed/36516449
http://dx.doi.org/10.1083/jcb.202211127
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author Varadarajan, Saranyaraajan
Raya-Sandino, Arturo
Nusrat, Asma
author_facet Varadarajan, Saranyaraajan
Raya-Sandino, Arturo
Nusrat, Asma
author_sort Varadarajan, Saranyaraajan
collection PubMed
description Maintenance of epithelial barrier function requires dynamic repair and remodeling of tight junctions. In this issue, Higashi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202204079) demonstrate that the proteolytic cleavage of EpCAM by membrane-anchored serine proteinases releases Claudin-7 to join tight junctions, suggesting a novel mechanism that couples sensing with repair of damaged tight junctions.
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spelling pubmed-97547012023-06-15 Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier Varadarajan, Saranyaraajan Raya-Sandino, Arturo Nusrat, Asma J Cell Biol Spotlight Maintenance of epithelial barrier function requires dynamic repair and remodeling of tight junctions. In this issue, Higashi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202204079) demonstrate that the proteolytic cleavage of EpCAM by membrane-anchored serine proteinases releases Claudin-7 to join tight junctions, suggesting a novel mechanism that couples sensing with repair of damaged tight junctions. Rockefeller University Press 2022-12-14 /pmc/articles/PMC9754701/ /pubmed/36516449 http://dx.doi.org/10.1083/jcb.202211127 Text en © 2022 Varadarajan et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Varadarajan, Saranyaraajan
Raya-Sandino, Arturo
Nusrat, Asma
Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title_full Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title_fullStr Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title_full_unstemmed Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title_short Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
title_sort clipping epcam to release claudin-7 for the greater good of the epithelial barrier
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754701/
https://www.ncbi.nlm.nih.gov/pubmed/36516449
http://dx.doi.org/10.1083/jcb.202211127
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AT nusratasma clippingepcamtoreleaseclaudin7forthegreatergoodoftheepithelialbarrier

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