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Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches

Dietary trans fatty acids (TFAs) are primarily industrially produced and remain abundant in processed food, particularly in low- and middle-income countries. Although TFAs are a cause of adverse cardiometabolic outcomes, little is known about exposure to TFAs in relation to brain development. We aim...

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Autores principales: Zou, Runyu, Labrecque, Jeremy A., Swanson, Sonja A., Steegers, Eric A. P., White, Tonya, El Marroun, Hanan, Tiemeier, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755085/
https://www.ncbi.nlm.nih.gov/pubmed/36107361
http://dx.doi.org/10.1007/s10654-022-00910-4
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author Zou, Runyu
Labrecque, Jeremy A.
Swanson, Sonja A.
Steegers, Eric A. P.
White, Tonya
El Marroun, Hanan
Tiemeier, Henning
author_facet Zou, Runyu
Labrecque, Jeremy A.
Swanson, Sonja A.
Steegers, Eric A. P.
White, Tonya
El Marroun, Hanan
Tiemeier, Henning
author_sort Zou, Runyu
collection PubMed
description Dietary trans fatty acids (TFAs) are primarily industrially produced and remain abundant in processed food, particularly in low- and middle-income countries. Although TFAs are a cause of adverse cardiometabolic outcomes, little is known about exposure to TFAs in relation to brain development. We aimed to investigate the effect of maternal TFA concentration during pregnancy on offspring head growth in utero and during childhood. In a prospective population-based study in Rotterdam, the Netherlands, with 6900 mother–child dyads, maternal plasma TFA concentration was assessed using gas chromatography in mid-gestation. Offspring head circumference (HC) was measured in the second and third trimesters using ultrasonography; childhood brain morphology was assessed using magnetic resonance imaging at age 10 years. We performed regression analyses adjusting for sociodemographic and lifestyle confounders and instrumental variable (IV) analyses. Our IV analysis leveraged a national policy change that led to a substantial reduction in TFA and occurred mid-recruitment. After adjusting for covariates, maternal TFA concentration during pregnancy was inversely related to fetal HC in the third trimester (mean difference per 1% wt:wt increase: − 0.33, 95% CI − 0.51, − 0.15, cm) and to fetal HC growth from the second to the third trimester (− 0.04, 95% CI − 0.06, − 0.02, cm/week). Consistent findings were obtained with IV analyses, strengthening a causal interpretation. Association between prenatal TFA exposure and HC in the second trimester or global brain volume at age 10 years was inconclusive. Our findings are of important public health relevance as TFA levels in food remain high in many countries. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10654-022-00910-4.
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spelling pubmed-97550852022-12-17 Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches Zou, Runyu Labrecque, Jeremy A. Swanson, Sonja A. Steegers, Eric A. P. White, Tonya El Marroun, Hanan Tiemeier, Henning Eur J Epidemiol Developmental Epidemiology Dietary trans fatty acids (TFAs) are primarily industrially produced and remain abundant in processed food, particularly in low- and middle-income countries. Although TFAs are a cause of adverse cardiometabolic outcomes, little is known about exposure to TFAs in relation to brain development. We aimed to investigate the effect of maternal TFA concentration during pregnancy on offspring head growth in utero and during childhood. In a prospective population-based study in Rotterdam, the Netherlands, with 6900 mother–child dyads, maternal plasma TFA concentration was assessed using gas chromatography in mid-gestation. Offspring head circumference (HC) was measured in the second and third trimesters using ultrasonography; childhood brain morphology was assessed using magnetic resonance imaging at age 10 years. We performed regression analyses adjusting for sociodemographic and lifestyle confounders and instrumental variable (IV) analyses. Our IV analysis leveraged a national policy change that led to a substantial reduction in TFA and occurred mid-recruitment. After adjusting for covariates, maternal TFA concentration during pregnancy was inversely related to fetal HC in the third trimester (mean difference per 1% wt:wt increase: − 0.33, 95% CI − 0.51, − 0.15, cm) and to fetal HC growth from the second to the third trimester (− 0.04, 95% CI − 0.06, − 0.02, cm/week). Consistent findings were obtained with IV analyses, strengthening a causal interpretation. Association between prenatal TFA exposure and HC in the second trimester or global brain volume at age 10 years was inconclusive. Our findings are of important public health relevance as TFA levels in food remain high in many countries. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10654-022-00910-4. Springer Netherlands 2022-09-15 2022 /pmc/articles/PMC9755085/ /pubmed/36107361 http://dx.doi.org/10.1007/s10654-022-00910-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Developmental Epidemiology
Zou, Runyu
Labrecque, Jeremy A.
Swanson, Sonja A.
Steegers, Eric A. P.
White, Tonya
El Marroun, Hanan
Tiemeier, Henning
Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title_full Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title_fullStr Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title_full_unstemmed Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title_short Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
title_sort prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches
topic Developmental Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755085/
https://www.ncbi.nlm.nih.gov/pubmed/36107361
http://dx.doi.org/10.1007/s10654-022-00910-4
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