Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB

Increased brain iron content has been consistently reported in sporadic Parkinson’s disease (PD) patients, and an increase in cytosolic free iron is known to cause oxidative stress and cell death. However, whether iron also accumulates in susceptible brain areas in humans or in mouse models of famil...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernández, Belén, Olmedo, Pablo, Gil, Fernando, Fdez, Elena, Naaldijk, Yahaira, Rivero-Ríos, Pilar, Bracher, Franz, Grimm, Christian, Churchill, Grant C., Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755144/
https://www.ncbi.nlm.nih.gov/pubmed/36522443
http://dx.doi.org/10.1038/s41419-022-05504-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755144/
https://www.ncbi.nlm.nih.gov/pubmed/36522443
http://dx.doi.org/10.1038/s41419-022-05504-2

Ejemplares similares