Cargando…

Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes

Diabetic nephropathy is characterized by excessive accumulation of extracellular matrix (ECM) leading to renal fibrosis, progressive deterioration of renal function, and eventually to end stage renal disease. Matrix metalloproteinases (MMPs) are known to regulate synthesis and degradation of the ECM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juin, Subir Kumar, Pushpakumar, Sathnur, Tyagi, Suresh C., Sen, Utpal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755213/ https://www.ncbi.nlm.nih.gov/pubmed/36522378 http://dx.doi.org/10.1038/s41598-022-25848-1

Ejemplares similares

GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling
por: Juin, Subir Kumar, et al.
Publicado: (2021)

Methylation-dependent antioxidant-redox imbalance regulates hypertensive kidney injury in aging
por: Pushpakumar, Sathnur, et al.
Publicado: (2020)

Anti-Parstatin Promotes Angiogenesis and Ameliorates Left Ventricular Dysfunction during Pressure Overload
por: Givvimani, Srikanth, et al.
Publicado: (2014)

Hydrogen Sulfide Protects Hyperhomocysteinemia-Induced Renal Damage by Modulation of Caveolin and eNOS Interaction
por: Pushpakumar, Sathnur, et al.
Publicado: (2019)

Matrix metalloproteinase inhibition mitigates renovascular remodeling in salt-sensitive hypertension
por: Pushpakumar, Sathnur B, et al.
Publicado: (2013)

Folic Acid Mitigates Angiotensin-II-Induced Blood Pressure and Renal Remodeling
por: Pushpakumar, Sathnur B., et al.
Publicado: (2013)

Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney
por: Pushpakumar, Sathnur, et al.
Publicado: (2017)

COVID-19 Mimics Pulmonary Dysfunction in Muscular Dystrophy as a Post-Acute Syndrome in Patients
por: Tyagi, Suresh C., et al.
Publicado: (2022)

Renal Denervation Helps Preserve the Ejection Fraction by Preserving Endocardial-Endothelial Function during Heart Failure
por: Pushpakumar, Sathnur, et al.
Publicado: (2023)

Exercise mitigates the effects of hyperhomocysteinemia on adverse muscle remodeling
por: Winchester, Lee J., et al.
Publicado: (2018)

GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney
por: John, AM Sashi Papu, et al.
Publicado: (2017)

Mitochondrial division/mitophagy inhibitor (Mdivi) Ameliorates Pressure Overload Induced Heart Failure
por: Givvimani, Srikanth, et al.
Publicado: (2012)

High Fat Diet Dysbiotic Mechanism of Decreased Gingival Blood Flow
por: Stanisic, Dragana, et al.
Publicado: (2021)

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications
por: Hossain, Uday, et al.
Publicado: (2020)

Epigenetics, 1-Carbon Metabolism, and Homocysteine During Dysbiosis
por: Singh, Mahavir, et al.
Publicado: (2021)

Mechanism of Blood–Heart-Barrier Leakage: Implications for COVID-19 Induced Cardiovascular Injury
por: Homme, Rubens P., et al.
Publicado: (2021)

Diabetic Nephropathy and Gaseous Modulators
por: Juin, Subir Kumar, et al.
Publicado: (2023)

Hydrogen sulfide mitigates skeletal muscle mitophagy‐led tissue remodeling via epigenetic regulation of the gene writer and eraser function
por: Singh, Mahavir, et al.
Publicado: (2022)

Simulation of COVID-19 symptoms in a genetically engineered mouse model: implications for the long haulers
por: Singh, Mahavir, et al.
Publicado: (2022)

Homocysteine and Hypertension in Diabetes: Does PPARγ Have a Regulatory Role?
por: Sen, Utpal, et al.
Publicado: (2010)

Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol
por: Mishra, Paras K, et al.
Publicado: (2010)

Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis
por: Zhang, Lingshu, et al.
Publicado: (2020)

A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis
por: Rai, Rahul, et al.
Publicado: (2017)

SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy
por: Liu, Lirong, et al.
Publicado: (2017)

Untapped diamonds for untamed diabetes: The α-glucosidase inhibitors
por: Kalra, Sanjay, et al.
Publicado: (2014)

α-glucosidase inhibitors from plants: A natural approach to treat diabetes
por: Kumar, Sunil, et al.
Publicado: (2011)

Ensete superbum ameliorates renal dysfunction in experimental diabetes mellitus
por: Sreekutty, MS, et al.
Publicado: (2016)

Blood flow interplays with elastin: collagen and MMP: TIMP ratios to maintain healthy vascular structure and function
por: Basu, Poulami, et al.
Publicado: (2010)

PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice
por: Rodriguez, Walter E., et al.
Publicado: (2008)

Alpha-glucosidase inhibitors in the early treatment of type 2 diabetes
por: van de Laar, Floris Alexander
Publicado: (2008)

Cinnamoyl Sucrose Esters as Alpha Glucosidase Inhibitors for the Treatment of Diabetes
por: Devaraj, Surabhi, et al.
Publicado: (2021)

Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
por: Li, Chun-jun, et al.
Publicado: (2012)

Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic db/db Mice
por: Zhao, Juan, et al.
Publicado: (2016)

Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy
por: Lu, Ailing, et al.
Publicado: (2020)

Chronic renal dysfunction in cirrhosis: A new frontier in hepatology
por: Kumar, Ramesh, et al.
Publicado: (2021)

Pneumatosis Intestinalis Induced by Alpha-Glucosidase Inhibitors in Patients with Diabetes Mellitus
por: McKinley, Blake J., et al.
Publicado: (2022)

Dahuang Fuzi Decoction Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in Chronic Aristolochic Acid Nephropathy
por: Shui, Guang-xing, et al.
Publicado: (2017)

Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10
por: Kesherwani, Varun, et al.
Publicado: (2015)

Knockout of KLF10 Ameliorated Diabetic Renal Fibrosis via Downregulation of DKK-1
por: Hsu, Yung-Chien, et al.
Publicado: (2022)

Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy
por: Wang, Shengju, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1krsmodaiauj2jfac807c52820