Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate

Owing to its ability to induce cellular senescence, inhibit PCNA, and arrest cell division cycle by negatively regulating CDKs as well as being a primary target of p53, p21 is traditionally considered a tumor suppressor. Nonetheless, several reports in recent years demonstrated its pro-oncogenic act...

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Detalles Bibliográficos
Autores principales: Maheshwari, Mayank, Yadav, Nisha, Hasanain, Mohammad, Pandey, Praveen, Sahai, Rohit, Choyal, Kuldeep, Singh, Akhilesh, Nengroo, Mushtaq A., Saini, Krishan K., Kumar, Deepak, Mitra, Kalyan, Datta, Dipak, Sarkar, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755229/
https://www.ncbi.nlm.nih.gov/pubmed/36522339
http://dx.doi.org/10.1038/s41419-022-05486-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755229/
https://www.ncbi.nlm.nih.gov/pubmed/36522339
http://dx.doi.org/10.1038/s41419-022-05486-1

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