Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes

Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. However, to further expand the therapeutic application of these tools there is a need for targetable systems that are small enough to be delivered efficiently. Here, we mined an extens...

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Detalles Bibliográficos
Autores principales: Aliaga Goltsman, Daniela S., Alexander, Lisa M., Lin, Jyun-Liang, Fregoso Ocampo, Rodrigo, Freeman, Benjamin, Lamothe, Rebecca C., Perez Rivas, Andres, Temoche-Diaz, Morayma M., Chadha, Shailaja, Nordenfelt, Natalie, Janson, Owen P., Barr, Ian, Devoto, Audra E., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755519/
https://www.ncbi.nlm.nih.gov/pubmed/36522342
http://dx.doi.org/10.1038/s41467-022-35257-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755519/
https://www.ncbi.nlm.nih.gov/pubmed/36522342
http://dx.doi.org/10.1038/s41467-022-35257-7

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