Cargando…
Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes
Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. However, to further expand the therapeutic application of these tools there is a need for targetable systems that are small enough to be delivered efficiently. Here, we mined an extens...
Autores principales: | Aliaga Goltsman, Daniela S., Alexander, Lisa M., Lin, Jyun-Liang, Fregoso Ocampo, Rodrigo, Freeman, Benjamin, Lamothe, Rebecca C., Perez Rivas, Andres, Temoche-Diaz, Morayma M., Chadha, Shailaja, Nordenfelt, Natalie, Janson, Owen P., Barr, Ian, Devoto, Audra E., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755519/ https://www.ncbi.nlm.nih.gov/pubmed/36522342 http://dx.doi.org/10.1038/s41467-022-35257-7 |
Ejemplares similares
-
Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability
por: Alexander, Lisa M., et al.
Publicado: (2023) -
Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering
por: Lamothe, Rebecca C., et al.
Publicado: (2023) -
New CRISPR-Cas systems from uncultivated microbes
por: Burstein, David, et al.
Publicado: (2016) -
Are Uncultivated Bacteria Really Uncultivable?
por: Puspita, Indun Dewi, et al.
Publicado: (2012) -
Novel Type V-A CRISPR Effectors Are Active Nucleases with Expanded Targeting Capabilities
por: Aliaga Goltsman, Daniela S., et al.
Publicado: (2020)