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Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis

BACKGROUND: Type I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1), as an i...

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Detalles Bibliográficos
Autores principales: An, Ni, Ge, Qinghua, Shao, Huihan, Li, Quanjie, Guo, Fei, Liang, Chen, Li, Xiaoyu, Yi, Dongrong, Yang, Long, Cen, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755837/
https://www.ncbi.nlm.nih.gov/pubmed/36532074
http://dx.doi.org/10.3389/fimmu.2022.1007718