Autologous bone marrow-derived MSCs engineered to express oFVIII-FLAG engraft in adult sheep and produce an effective increase in plasma FVIII levels

INTRODUCTION: Hemophilia A (HA) is the most common X-linked bleeding disorder, occurring in 1 in 5,000 live male births and affecting >1 million individuals worldwide. Although advances in protein-based HA therapeutics have improved health outcomes, current standard-of-care requires infusion 2-3...

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Detalles Bibliográficos
Autores principales: Trevisan, Brady, Rodriguez, Martin, Medder, Hailey, Lankford, Shannon, Combs, Rebecca, Owen, John, Atala, Anthony, Porada, Christopher D., Almeida-Porada, Graça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755880/
https://www.ncbi.nlm.nih.gov/pubmed/36532079
http://dx.doi.org/10.3389/fimmu.2022.1070476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755880/
https://www.ncbi.nlm.nih.gov/pubmed/36532079
http://dx.doi.org/10.3389/fimmu.2022.1070476

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