Population pharmacokinetic‐pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease

Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer. This article describes the population pharmacokinetic (PK) and PK/pharmacodynamic (PD) analyses for amyloid plaques, as measured usi...

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Detalles Bibliográficos
Autores principales: Hayato, Seiichi, Takenaka, Osamu, Sreerama Reddy, Sree Harsha, Landry, Ishani, Reyderman, Larisa, Koyama, Akihiko, Swanson, Chad, Yasuda, Sanae, Hussein, Ziad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755918/
https://www.ncbi.nlm.nih.gov/pubmed/36165093
http://dx.doi.org/10.1002/psp4.12862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755918/
https://www.ncbi.nlm.nih.gov/pubmed/36165093
http://dx.doi.org/10.1002/psp4.12862

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