SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis

Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity of tumor cells, and colorectal cancer stem cells that reside at the top of the intratumoral hierarchy are especially dependent on this feature. By performing disease modeling on patient-derived tumor organoi...

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Detalles Bibliográficos
Autores principales: Loevenich, Leon P., Tschurtschenthaler, Markus, Rokavec, Matjaz, Silva, Miguel G., Jesinghaus, Moritz, Kirchner, Thomas, Klauschen, Frederick, Saur, Dieter, Neumann, Jens, Hermeking, Heiko, Jung, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755967/
https://www.ncbi.nlm.nih.gov/pubmed/36219392
http://dx.doi.org/10.1158/0008-5472.CAN-22-1247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755967/
https://www.ncbi.nlm.nih.gov/pubmed/36219392
http://dx.doi.org/10.1158/0008-5472.CAN-22-1247

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