Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs

BACKGROUND: Pulmonary hypertension (PH) is characterized by progressive pulmonary arterial remodelling, associated with different severities of inflammation and altered immune processes. Disulfiram eliminates the formation of N-gasdermin D (GSDMD) plasma membrane pores to prevent pyroptosis. Pyropto...

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Detalles Bibliográficos
Autores principales: Hu, Shunlian, Wang, Lu, Xu, Yahan, Li, Fajiu, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756478/
https://www.ncbi.nlm.nih.gov/pubmed/36527086
http://dx.doi.org/10.1186/s12931-022-02279-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756478/
https://www.ncbi.nlm.nih.gov/pubmed/36527086
http://dx.doi.org/10.1186/s12931-022-02279-0

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