A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products

Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict drug pharmacokinetics (PK). This includes the use of dermal PBPK models at the regulatory level including virtual bioequivalence (VBE) studies. The current work considers the Topicort(®) Sp...

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Detalles Bibliográficos
Autores principales: Clarke, J. F., Thakur, K., Polak, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756572/
https://www.ncbi.nlm.nih.gov/pubmed/36532731
http://dx.doi.org/10.3389/fphar.2022.1007496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756572/
https://www.ncbi.nlm.nih.gov/pubmed/36532731
http://dx.doi.org/10.3389/fphar.2022.1007496

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