Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system

BACKGROUND: Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modifications. Successful germline transmission of a transgene from...

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Detalles Bibliográficos
Autores principales: Horii, Takuro, Morita, Sumiyo, Kimura, Mika, Hatada, Izuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756621/
https://www.ncbi.nlm.nih.gov/pubmed/36522780
http://dx.doi.org/10.1186/s13072-022-00474-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756621/
https://www.ncbi.nlm.nih.gov/pubmed/36522780
http://dx.doi.org/10.1186/s13072-022-00474-3

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