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Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system

BACKGROUND: Epigenome-edited animal models enable direct demonstration of disease causing epigenetic mutations. Transgenic (TG) mice stably expressing epigenome-editing factors exhibit dramatic and stable changes in target epigenome modifications. Successful germline transmission of a transgene from...

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Detalles Bibliográficos
Autores principales:	Horii, Takuro, Morita, Sumiyo, Kimura, Mika, Hatada, Izuho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756621/ https://www.ncbi.nlm.nih.gov/pubmed/36522780 http://dx.doi.org/10.1186/s13072-022-00474-3

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