SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

INTRODUCTION: Colorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1). RESULTS: In this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-ligand 10 (CXCL10), a T-cell-attractant...

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Detalles Bibliográficos
Autores principales: Tan, Tze Guan, Zybina, Yulia, McKenna, Cooper, Olow, Aleksandra, Rukmini, Subhadra Jayaraman, Wong, Michael Thomas, Sadekova, Svetlana, Chackerian, Alissa, Bauché, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756846/
https://www.ncbi.nlm.nih.gov/pubmed/36531014
http://dx.doi.org/10.3389/fonc.2022.1016307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756846/
https://www.ncbi.nlm.nih.gov/pubmed/36531014
http://dx.doi.org/10.3389/fonc.2022.1016307

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