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3D chromatin connectivity underlies replication origin efficiency in mouse embryonic stem cells
In mammalian cells, chromosomal replication starts at thousands of origins at which replisomes are assembled. Replicative stress triggers additional initiation events from ‘dormant’ origins whose genomic distribution and regulation are not well understood. In this study, we have analyzed origin acti...
Autores principales: | Jodkowska, Karolina, Pancaldi, Vera, Rigau, Maria, Almeida, Ricardo, Fernández-Justel, José M, Graña-Castro, Osvaldo, Rodríguez-Acebes, Sara, Rubio-Camarillo, Miriam, Carrillo-de Santa Pau, Enrique, Pisano, David, Al-Shahrour, Fátima, Valencia, Alfonso, Gómez, María, Méndez, Juan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757045/ https://www.ncbi.nlm.nih.gov/pubmed/36453993 http://dx.doi.org/10.1093/nar/gkac1111 |
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