Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers

Most cancer alterations occur in the noncoding portion of the human genome, where regulatory regions control gene expression. The discovery of noncoding mutations altering the cells’ regulatory programs has been limited to few examples with high recurrence or high functional impact. Here, we show th...

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Detalles Bibliográficos
Autores principales: Castro-Mondragon, Jaime A, Aure, Miriam Ragle, Lingjærde, Ole Christian, Langerød, Anita, Martens, John W M, Børresen-Dale, Anne-Lise, Kristensen, Vessela N, Mathelier, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757053/
https://www.ncbi.nlm.nih.gov/pubmed/36477895
http://dx.doi.org/10.1093/nar/gkac1143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757053/
https://www.ncbi.nlm.nih.gov/pubmed/36477895
http://dx.doi.org/10.1093/nar/gkac1143

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