Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases

The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has roles in lipid metabolism by altering mRNA coding, adaptive immunity by causing evolution of antibody genes, and innate immunity thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Lai, Sami, Alina, Chelico, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Critical Reviews and Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757055/
https://www.ncbi.nlm.nih.gov/pubmed/36444883
http://dx.doi.org/10.1093/nar/gkac1121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757055/
https://www.ncbi.nlm.nih.gov/pubmed/36444883
http://dx.doi.org/10.1093/nar/gkac1121

Ejemplares similares