Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries

BACKGROUND: The amplification of GTP cyclohydrolase 1 (pfgch1) in Plasmodium falciparum has been linked to the upregulation of the pfdhfr and pfdhps genes associated with resistance to the antimalarial drug sulfadoxine-pyrimethamine. During the 1990s and 2000s, sulfadoxine-pyrimethamine was withdraw...

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Detalles Bibliográficos
Autores principales: Srisutham, Suttipat, Madmanee, Wanassanan, Kouhathong, Jindarat, Sutawong, Kreepol, Tripura, Rupam, Peto, Thomas J., van der Pluijm, Rob W., Callery, James J., Dysoley, Lek, Mayxay, Mayfong, Newton, Paul N., Pongvongsa, Tiengkham, Hongvanthong, Bouasy, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Imwong, Mallika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757559/
https://www.ncbi.nlm.nih.gov/pubmed/36525403
http://dx.doi.org/10.1371/journal.pone.0278928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757559/
https://www.ncbi.nlm.nih.gov/pubmed/36525403
http://dx.doi.org/10.1371/journal.pone.0278928

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