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Ten-year persistence and evolution of Plasmodium falciparum antifolate and anti-sulfonamide resistance markers pfdhfr and pfdhps in three Asian countries
BACKGROUND: The amplification of GTP cyclohydrolase 1 (pfgch1) in Plasmodium falciparum has been linked to the upregulation of the pfdhfr and pfdhps genes associated with resistance to the antimalarial drug sulfadoxine-pyrimethamine. During the 1990s and 2000s, sulfadoxine-pyrimethamine was withdraw...
Autores principales: | Srisutham, Suttipat, Madmanee, Wanassanan, Kouhathong, Jindarat, Sutawong, Kreepol, Tripura, Rupam, Peto, Thomas J., van der Pluijm, Rob W., Callery, James J., Dysoley, Lek, Mayxay, Mayfong, Newton, Paul N., Pongvongsa, Tiengkham, Hongvanthong, Bouasy, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Imwong, Mallika |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757559/ https://www.ncbi.nlm.nih.gov/pubmed/36525403 http://dx.doi.org/10.1371/journal.pone.0278928 |
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