Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications

Improvements to the production of proteins in industrial yeast species have largely relied on generating variation in a single genetic background. A new study in PLOS Biology leverages natural genetic variation to identify genes and variants with the potential to improve protein yield.

Detalles Bibliográficos
Autores principales: Swichkow, Chantle Reiko, Bloom, Joshua S., Kruglyak, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Primer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757564/
https://www.ncbi.nlm.nih.gov/pubmed/36525401
http://dx.doi.org/10.1371/journal.pbio.3001911
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author Swichkow, Chantle Reiko
Bloom, Joshua S.
Kruglyak, Leonid
author_facet Swichkow, Chantle Reiko
Bloom, Joshua S.
Kruglyak, Leonid
author_sort Swichkow, Chantle Reiko
collection PubMed
description Improvements to the production of proteins in industrial yeast species have largely relied on generating variation in a single genetic background. A new study in PLOS Biology leverages natural genetic variation to identify genes and variants with the potential to improve protein yield.
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spelling pubmed-97575642022-12-17 Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications Swichkow, Chantle Reiko Bloom, Joshua S. Kruglyak, Leonid PLoS Biol Primer Improvements to the production of proteins in industrial yeast species have largely relied on generating variation in a single genetic background. A new study in PLOS Biology leverages natural genetic variation to identify genes and variants with the potential to improve protein yield. Public Library of Science 2022-12-16 /pmc/articles/PMC9757564/ /pubmed/36525401 http://dx.doi.org/10.1371/journal.pbio.3001911 Text en © 2022 Swichkow et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Swichkow, Chantle Reiko
Bloom, Joshua S.
Kruglyak, Leonid
Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title_full Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title_fullStr Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title_full_unstemmed Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title_short Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications
title_sort exploring the genetic architecture of protein secretion in komagataella phaffii (pichia pastoris) for biotechnology applications
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757564/
https://www.ncbi.nlm.nih.gov/pubmed/36525401
http://dx.doi.org/10.1371/journal.pbio.3001911
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AT kruglyakleonid exploringthegeneticarchitectureofproteinsecretioninkomagataellaphaffiipichiapastorisforbiotechnologyapplications

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