Modeling long QT syndrome type 2 on-a-chip via in-depth assessment of isogenic gene-edited 3D cardiac tissues

Long QT syndrome (LQTS) is a cardiovascular disease characterized by QT interval prolongation that can lead to sudden cardiac death. Many mutations with heterogeneous mechanisms have been identified in KCNH2, the gene that encodes for hERG (Kv11.1), which lead to onset of LQTS type 2 (LQTS2). In thi...

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Detalles Bibliográficos
Autores principales: Veldhuizen, Jaimeson, Mann, Helen F., Karamanova, Nina, Van Horn, Wade D., Migrino, Raymond Q., Brafman, David, Nikkhah, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757749/
https://www.ncbi.nlm.nih.gov/pubmed/36525500
http://dx.doi.org/10.1126/sciadv.abq6720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757749/
https://www.ncbi.nlm.nih.gov/pubmed/36525500
http://dx.doi.org/10.1126/sciadv.abq6720

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