Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained challenging. Here, we utilise clonal transcriptomics...

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Detalles Bibliográficos
Autores principales: Wild, Sophia A, Cannell, Ian G, Nicholls, Ashley, Kania, Katarzyna, Bressan, Dario, Hannon, Gregory J, Sawicka, Kirsty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757829/
https://www.ncbi.nlm.nih.gov/pubmed/36525288
http://dx.doi.org/10.7554/eLife.80981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757829/
https://www.ncbi.nlm.nih.gov/pubmed/36525288
http://dx.doi.org/10.7554/eLife.80981

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