Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition

Fatty acid uptake is essential for cell physiological function, but detailed mechanisms remain unclear. Here, we generated an acetyl-CoA carboxylases (ACC1/2) double-knockout cell line, which lacked fatty acid biosynthesis and survived on serum fatty acids and was used to screen for fatty acid uptak...

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Detalles Bibliográficos
Autores principales: Chu, Qiaoyun, An, Jing, Liu, Ping, Song, Yihan, Zhai, Xuewei, Yang, Ronghui, Niu, Jing, Yang, Chuanzhen, Li, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757841/
https://www.ncbi.nlm.nih.gov/pubmed/36520461
http://dx.doi.org/10.1084/jem.20221316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757841/
https://www.ncbi.nlm.nih.gov/pubmed/36520461
http://dx.doi.org/10.1084/jem.20221316

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