De novo design of obligate ABC-type heterotrimeric proteins

The de novo design of three protein chains that associate to form a heterotrimer (but not any of the possible two-chain heterodimers) and that can drive the assembly of higher-order branching structures is an important challenge for protein design. We designed helical heterotrimers with specificity...

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Detalles Bibliográficos
Autores principales: Bermeo, Sherry, Favor, Andrew, Chang, Ya-Ting, Norris, Andrew, Boyken, Scott E., Hsia, Yang, Haddox, Hugh K., Xu, Chunfu, Brunette, T. J., Wysocki, Vicki H., Bhabha, Gira, Ekiert, Damian C., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758053/
https://www.ncbi.nlm.nih.gov/pubmed/36522429
http://dx.doi.org/10.1038/s41594-022-00879-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758053/
https://www.ncbi.nlm.nih.gov/pubmed/36522429
http://dx.doi.org/10.1038/s41594-022-00879-4

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