Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein

Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies. α-synuclein (α-syn) species truncated at the carboxy-terminal (C-terminal) accumulate in pathological inclusi...

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Detalles Bibliográficos
Autores principales: Santulli, Chiara, Bon, Carlotta, De Cecco, Elena, Codrich, Marta, Narkiewicz, Joanna, Parisse, Pietro, Perissinotto, Fabio, Santoro, Claudio, Persichetti, Francesca, Legname, Giuseppe, Espinoza, Stefano, Gustincich, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758156/
https://www.ncbi.nlm.nih.gov/pubmed/36526614
http://dx.doi.org/10.1038/s41419-022-05489-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758156/
https://www.ncbi.nlm.nih.gov/pubmed/36526614
http://dx.doi.org/10.1038/s41419-022-05489-y

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