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Engineering a two-gene system to operate as a highly sensitive biosensor or a sharp switch upon induction with β-estradiol
The human estrogen receptor has been used for about thirty years, in the yeast S. cerevisiae, as a component of chimeric transcription factors. Its ligand, β-estradiol, permits to control the protein translocation into the nucleus and, as a consequence, the expression of the gene(s) targeted by the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758199/ https://www.ncbi.nlm.nih.gov/pubmed/36526685 http://dx.doi.org/10.1038/s41598-022-26195-x |