Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis

There are no available therapies targeting the underlying molecular mechanisms of neurodegenerative diseases. Although chaperone therapies that alleviate endoplasmic reticulum (ER) stress recently showed promise in the treatment of neurodegenerative diseases, the detailed mechanisms remain unclear....

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Detalles Bibliográficos
Autores principales: Sugiyama, Takashi, Murao, Naoya, Kadowaki, Hisae, Nishitoh, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759528/
https://www.ncbi.nlm.nih.gov/pubmed/36528738
http://dx.doi.org/10.1038/s41598-022-26370-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759528/
https://www.ncbi.nlm.nih.gov/pubmed/36528738
http://dx.doi.org/10.1038/s41598-022-26370-0

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