The reverse mode of the Na(+)/Ca(2+) exchanger contributes to the pacemaker mechanism in rabbit sinus node cells

Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-channels and intracellular Ca(2+)-handling. The fundamental role of the inward Na(+)/Ca(2+) exchanger (NCX) is firmly established. However, little is known about the reverse mode exchange. A simulation study attributed im...

Descripción completa

Detalles Bibliográficos
Autores principales: Tóth, Noémi, Loewe, Axel, Szlovák, Jozefina, Kohajda, Zsófia, Bitay, Gergő, Levijoki, Jouko, Papp, Julius Gy., Varró, András, Nagy, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759562/
https://www.ncbi.nlm.nih.gov/pubmed/36528651
http://dx.doi.org/10.1038/s41598-022-25574-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759562/
https://www.ncbi.nlm.nih.gov/pubmed/36528651
http://dx.doi.org/10.1038/s41598-022-25574-8

Ejemplares similares