Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The Streptococcus pyogenes bacterium secretes the protease IdeS and the glycosidase EndoS, which specifically catalyse cleavage and deglycosylation of human IgG, respectively. Id...

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Detalles Bibliográficos
Autores principales: Sudol, Abigail S. L., Butler, John, Ivory, Dylan P., Tews, Ivo, Crispin, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759587/
https://www.ncbi.nlm.nih.gov/pubmed/36528711
http://dx.doi.org/10.1038/s41467-022-35340-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759587/
https://www.ncbi.nlm.nih.gov/pubmed/36528711
http://dx.doi.org/10.1038/s41467-022-35340-z

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