Evolving DNA repair synthetic lethality targets in cancer

DNA damage signaling response and repair (DDR) is a critical defense mechanism against genomic instability. Impaired DNA repair capacity is an important risk factor for cancer development. On the other hand, up-regulation of DDR mechanisms is a feature of cancer chemotherapy and radiotherapy resista...

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Detalles Bibliográficos
Autores principales: Kulkarni, Sanat, Brownlie, Juliette, Jeyapalan, Jennie N., Mongan, Nigel P., Rakha, Emad A., Madhusudan, Srinivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760629/
https://www.ncbi.nlm.nih.gov/pubmed/36420962
http://dx.doi.org/10.1042/BSR20221713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760629/
https://www.ncbi.nlm.nih.gov/pubmed/36420962
http://dx.doi.org/10.1042/BSR20221713

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