Localization of Mycobacterium tuberculosis topoisomerase I C-terminal sequence motif required for inhibition by endogenous toxin MazF4

Only about half the multi-drug resistant tuberculosis (MDR-TB) cases are successfully cured. Thus, there is an urgent need of new TB treatment against a novel target. Mycobacterium tuberculosis (Mtb) topoisomerase I (TopA) is the only type IA topoisomerase in this organism and has been validated as...

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Detalles Bibliográficos
Autores principales: Garcia, Pamela K., Martinez Borrero, Rosemarie, Annamalai, Thirunavukkarasu, Diaz, Esnel, Balarezo, Steve, Tiwari, Purushottam B., Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760754/
https://www.ncbi.nlm.nih.gov/pubmed/36545199
http://dx.doi.org/10.3389/fmicb.2022.1032320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760754/
https://www.ncbi.nlm.nih.gov/pubmed/36545199
http://dx.doi.org/10.3389/fmicb.2022.1032320

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