Fiber manipulation and post-assembly nanobody conjugation for adenoviral vector retargeting through SpyTag-SpyCatcher protein ligation

For adenoviruses (Ads) to be optimally effective in cancer theranostics, they need to be retargeted toward target cells and lose their natural tropism. Typically, this is accomplished by either engineering fiber proteins and/or employing bispecific adapters, capable of bonding Ad fibers and tumor an...

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Detalles Bibliográficos
Autores principales: Kadkhodazadeh, Maryam, Mohajel, Nasir, Behdani, Mahdi, Baesi, Kazem, Khodaei, Behzad, Azadmanesh, Kayhan, Arashkia, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760943/
https://www.ncbi.nlm.nih.gov/pubmed/36545512
http://dx.doi.org/10.3389/fmolb.2022.1039324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9760943/
https://www.ncbi.nlm.nih.gov/pubmed/36545512
http://dx.doi.org/10.3389/fmolb.2022.1039324

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