Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape

BACKGROUND: Intratumoral heterogeneity (ITH) is a hallmark of clear cell renal cell carcinoma (ccRCC) that reflects the trajectory of evolution and influences clinical prognosis. Here, we seek to elucidate how ITH and tumor evolution during immune checkpoint inhibitor (ICI) treatment can lead to the...

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Detalles Bibliográficos
Autores principales: Golkaram, Mahdi, Kuo, Fengshen, Gupta, Sounak, Carlo, Maria I., Salmans, Michael L., Vijayaraghavan, Raakhee, Tang, Cerise, Makarov, Vlad, Rappold, Phillip, Blum, Kyle A., Zhao, Chen, Mehio, Rami, Zhang, Shile, Godsey, Jim, Pawlowski, Traci, DiNatale, Renzo G., Morris, Luc G. T., Durack, Jeremy, Russo, Paul, Kotecha, Ritesh R., Coleman, Jonathan, Chen, Ying-Bei, Reuter, Victor E., Motzer, Robert J., Voss, Martin H., Liu, Li, Reznik, Ed, Chan, Timothy A., Hakimi, A. Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762114/
https://www.ncbi.nlm.nih.gov/pubmed/36536472
http://dx.doi.org/10.1186/s13073-022-01146-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762114/
https://www.ncbi.nlm.nih.gov/pubmed/36536472
http://dx.doi.org/10.1186/s13073-022-01146-3

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