Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis

Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic acid (QA) decline w...

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Detalles Bibliográficos
Autores principales: Xu, Bowen, Zhang, Peng, Tang, Xiaolong, Wang, Shiguan, Shen, Jing, Zheng, Yuanwen, Gao, Chao, Mi, Ping, Zhang, Cuijuan, Qu, Hui, Li, Shiyang, Yuan, Detian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762284/
https://www.ncbi.nlm.nih.gov/pubmed/36310151
http://dx.doi.org/10.1002/advs.202204697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762284/
https://www.ncbi.nlm.nih.gov/pubmed/36310151
http://dx.doi.org/10.1002/advs.202204697

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