Combinatorial CRISPR/Cas9 Screening Reveals Epistatic Networks of Interacting Tumor Suppressor Genes and Therapeutic Targets in Human Breast Cancer

The majority of cancers are driven by multiple genetic alterations, but how these changes collaborate during tumorigenesis remains largely unknown. To gain mechanistic insights into tumor-promoting genetic interactions among tumor suppressor genes (TSG), we conducted combinatorial CRISPR screening c...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Xiaoyu, Li, Jinyu, Liu, Zhimin, Powers, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Genome and Epigenome
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762330/
https://www.ncbi.nlm.nih.gov/pubmed/34561273
http://dx.doi.org/10.1158/0008-5472.CAN-21-2555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762330/
https://www.ncbi.nlm.nih.gov/pubmed/34561273
http://dx.doi.org/10.1158/0008-5472.CAN-21-2555

Ejemplares similares