Cargando…
IRF2 is required for development and functional maturation of human NK cells
Natural killer (NK) cells are cytotoxic and cytokine-producing lymphocytes that play an important role in the first line of defense against malignant or virus-infected cells. A better understanding of the transcriptional regulation of human NK cell differentiation is crucial to improve the efficacy...
Autores principales: | Persyn, Eva, Wahlen, Sigrid, Kiekens, Laura, Van Loocke, Wouter, Siwe, Hannah, Van Ammel, Els, De Vos, Zenzi, Van Nieuwerburgh, Filip, Matthys, Patrick, Taghon, Tom, Vandekerckhove, Bart, Van Vlierberghe, Pieter, Leclercq, Georges |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762550/ https://www.ncbi.nlm.nih.gov/pubmed/36544762 http://dx.doi.org/10.3389/fimmu.2022.1038821 |
Ejemplares similares
-
TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality
por: Persyn, Eva, et al.
Publicado: (2022) -
The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency
por: Wahlen, Sigrid, et al.
Publicado: (2022) -
T-BET and EOMES Accelerate and Enhance Functional Differentiation of Human Natural Killer Cells
por: Kiekens, Laura, et al.
Publicado: (2021) -
T-BET drives the conversion of human type 3 innate lymphoid cells into functional NK cells
por: Kiekens, Laura, et al.
Publicado: (2022) -
HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development
por: De Decker, Matthias, et al.
Publicado: (2020)