PROTAC: targeted drug strategy. Principles and limitations

The PROTAC (PROteolysis TArgeting Chimera) technology is a method of targeting intracellular proteins previously considered undruggable. This technology utilizes the ubiquitin—proteasome system in cells to specifically degrade target proteins, thereby offering significant advantages over conventiona...

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Detalles Bibliográficos
Autores principales: Koroleva, O. A., Dutikova, Yu. V., Trubnikov, A. V., Zenov, F. A., Manasova, E. V., Shtil, A. A., Kurkin, A. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762658/
https://www.ncbi.nlm.nih.gov/pubmed/36569659
http://dx.doi.org/10.1007/s11172-022-3659-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762658/
https://www.ncbi.nlm.nih.gov/pubmed/36569659
http://dx.doi.org/10.1007/s11172-022-3659-z

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