Thiopurine 6TG treatment increases tumor immunogenicity and response to immune checkpoint blockade

Immune-checkpoint inhibitors (ICI) are highly effective in reinvigorating T cells to attack cancer. Nevertheless, a large subset of patients fails to benefit from ICI, partly due to lack of the cancer neoepitopes necessary to trigger an immune response. In this study, we used the thiopurine 6-thiogu...

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Detalles Bibliográficos
Autores principales: Nazerai, Loulieta, Willis, Shona Caroline, Yankilevich, Patricio, Di Leo, Luca, Bosisio, Francesca Maria, Frias, Alex, Bertolotto, Corine, Nersting, Jacob, Thastrup, Maria, Buus, Soren, Thomsen, Allan Randrup, Nielsen, Morten, Rohrberg, Kristoffer Staal, Schmiegelow, Kjeld, De Zio, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762757/
https://www.ncbi.nlm.nih.gov/pubmed/36545256
http://dx.doi.org/10.1080/2162402X.2022.2158610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762757/
https://www.ncbi.nlm.nih.gov/pubmed/36545256
http://dx.doi.org/10.1080/2162402X.2022.2158610

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