ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer

Immunosuppressive tumor microenvironment (TME) impedes anti-tumor immune responses and contributes to immunotherapy resistance in triple-negative breast cancer (TNBC). ADAM12, a member of cell surface metalloproteases, is selectively upregulated in mesenchymal/claudin-low TNBCs, where its expression...

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Detalles Bibliográficos
Autores principales: Wang, Guanpeng, Romero, Yeni, Thevarajan, Indhujah, Zolkiewska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762783/
https://www.ncbi.nlm.nih.gov/pubmed/36545255
http://dx.doi.org/10.1080/2162402X.2022.2158006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762783/
https://www.ncbi.nlm.nih.gov/pubmed/36545255
http://dx.doi.org/10.1080/2162402X.2022.2158006

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