Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease

Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were obser...

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Detalles Bibliográficos
Autores principales: Zhang, Changjun, Zhang, Yujia, Lv, Yangjing, Guo, Jianan, Gao, Bianbian, Lu, Yi, Zang, Anjie, Zhu, Xi, Zhou, Tao, Xie, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762789/
https://www.ncbi.nlm.nih.gov/pubmed/36519319
http://dx.doi.org/10.1080/14756366.2022.2134358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762789/
https://www.ncbi.nlm.nih.gov/pubmed/36519319
http://dx.doi.org/10.1080/14756366.2022.2134358

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