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Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
Receptor occupancy assays applied in clinical studies provide insights into pharmacokinetic-pharmacodynamic relationships for therapeutic antibodies. When measured by different assays, however, receptor occupancy results can be controversial, as was observed for nivolumab, a monoclonal antibody targ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762804/ https://www.ncbi.nlm.nih.gov/pubmed/36524835 http://dx.doi.org/10.1080/19420862.2022.2156317 |