Alternative processing of human HTT mRNA with implications for Huntington’s disease therapeutics

Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene (HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We previously showed that HTT mRNA carrying an expanded CAG repeat was incompletely spliced to generate HTT1a, an exon 1 only...

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Detalles Bibliográficos
Autores principales: Fienko, Sandra, Landles, Christian, Sathasivam, Kirupa, McAteer, Sean J, Milton, Rebecca E, Osborne, Georgina F, Smith, Edward J, Jones, Samuel T, Bondulich, Marie K, Danby, Emily C E, Phillips, Jemima, Taxy, Bridget A, Kordasiewicz, Holly B, Bates, Gillian P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762945/
https://www.ncbi.nlm.nih.gov/pubmed/35793238
http://dx.doi.org/10.1093/brain/awac241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762945/
https://www.ncbi.nlm.nih.gov/pubmed/35793238
http://dx.doi.org/10.1093/brain/awac241

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